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Mothers’ age at menopause may predict daughters’ ovarian reserve

7 November 2012

A mother’s age at menopause may predict her daughter’s fertility in terms of the numbers of eggs remaining in her ovaries, according to the new research published online in Europe’s leading reproductive medicine journal Human Reproduction.

By assessing ovarian reserve with two accepted methods – levels of anti-Müllerian hormone (AMH) and antral follicle count (AFC) – in daughters and comparing it with the age of menopause in their mothers, researchers found that both AMH and AFC declined faster in women whose mothers had an early menopause compared to women whose mothers had a late menopause. The number of eggs remaining in a woman’s ovary is related to a reduction in her ability to conceive naturally, with both the number and quality of eggs starting to decline as she gets older.

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