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NAR Top Articles - Synthetic Biology and Chemistry

Synthetic Biology and Chemistry

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March 2016


CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences
Lin, YN; Cradick, TJ; Brown, MT; Deshmukh, H; Ranjan, P; Sarode, N; Wile, BM; Vertino, PM; Stewart, FJ; Bao, G
Nucleic Acids Res. 2014, 42, 7473-7485
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Targeted delivery of antisense oligonucleotides to hepatocytes using triantennary N-acetyl galactosamine improves potency 10-fold in mice
Prakash, TP; Graham, MJ; Yu, JH; Carty, R; Low, A; Chappell, A; Schmidt, K; Zhao, CG; Aghajan, M; Murray, HF; Riney, S; Booten, SL; Murray, SF; Gaus, H; Crosby, J; Lima, WF; Guo, SL; Monia, BP; Swayze, EE; Seth, PP
Nucleic Acids Res. 2014, 42, 8796-8807
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Large chromosomal deletions and heritable small genetic changes induced by CRISPR/Cas9 in rice
Zhou, HB; Liu, B; Weeks, DP; Spalding, MH; Yang, B
Nucleic Acids Res. 2014, 42, 10903-10914
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Synthetic biosensors for precise gene control and real-time monitoring of metabolites
Rogers, Jameson K.; Guzman, Christopher D.; Taylor, Noah D.; Raman, Srivatsan; Anderson, Kelley; Church, George M.
Nucleic Acids Res. 2015, 43, 7648-7660
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A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
O'Geen, Henriette; Henry, Isabelle M.; Bhakta, Mital S.; Meckler, Joshua F.; Segal, David J.
Nucleic Acids Res. 2015, 43, 3389-3404
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CRISPR-based self-cleaving mechanism for controllable gene delivery in human cells
Moore, Richard; Spinhirne, Alec; Lai, Michael J.; Preisser, Samantha; Li, Yi; Kang, Taek; Bleris, Leonidas
Nucleic Acids Res. 2015, 43, 1297-1303
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A predictive biophysical model of translational coupling to coordinate and control protein expression in bacterial operons
Tian, Tian; Salis, Howard M.
Nucleic Acids Res. 2015, 43, 7137-7151
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Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
Luo, Michelle L.; Mullis, Adam S.; Leenay, Ryan T.; Beisel, Chase L.
Nucleic Acids Res. 2015, 43, 674-681
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A split intein T7 RNA polymerase for transcriptional AND-logic
Schaerli, Y; Gili, M; Isalan, M
Nucleic Acids Res. 2014, 42, 12322-12328
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A platform for rapid prototyping of synthetic gene networks in mammalian cells
Duportet, X; Wroblewska, L; Guye, P; Li, YQ; Eyquem, J; Rieders, J; Rimchala, T; Batt, G; Weiss, R
Nucleic Acids Res. 2014, 42, 13440-13451
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